For example, point-of-care C-reactive protein (CRP) measurement is increasingly available and recommended by guidelines to aid in diagnosis and management of pneumonia in adults.19–22 Although there is currently no accurate biomarker available to distinguish between a bacterial or viral infection,23 biomarkers may support correct identification of children at risk of serious infections in ambulatory care.24 This might help primary care physicians decide which children with suspected pneumonia need to be more closely monitored or who might benefit from antibiotic treatment. The gene discussed is CRP; the disease is pneumonia.