RYR2 and cancer: Key replicated genes included the mutational cancer drivers MTOR and SDK1, and three calcium signaling-related genes RYR1, CACNA1H and RYR2. Of note, MTOR has been determined to be an HCC driver gene using MutSigCV42, and was identified to be one of the most important genes associated with NASH-HCC in this study, suggesting the special significance of MTOR mutations in this subtype of HCC.