In NASH-HCCs, the 16 mutated genes involved in insulin signaling included insulin receptor (Insr) and some other well-known cancer-related genes (Mtor, Hras1, Akt3, etc), with Mtor and Hras1 recurrently mutated (Fig. 6c). This evidence concerns the gene AKT3 and metabolic dysfunction-associated steatohepatitis.