Mounting evidence from work in mice has demonstrated that many of the complications of overnutrition, including cardiovascular disease, appetitive dysregulation, and insulin resistance, result in part from a state of chronic low-grade inflammation induced by activation of IKK signaling and NF-κB-mediated transcription within both the hypothalamus and peripheral tissues such as the liver and fat (Arkan et al. 2005). The gene discussed is NFKB1; the disease is cardiovascular disorder.