Transient knock-down of both TGFB1 and DVL2 by specific siRNAs (knock-down efficiency: Supplementary Figure S1) reduced the migratory capabilities of GBM cells in 2D migration assays (Figure 3B), thereby closing the anticipated functional loop; miR-744 impairs migration of human glioma cells by direct targeting of TGFB1 and DVL2. The gene discussed is TGFB1; the disease is central nervous system cancer.