Inhibition of TGFB1 by miR-744 thus fulfills a dual role in mediating effects of this intronic miRNA on its host MAP2K4: (i) Functional antagonization via blocking SMAD-signaling, thereby reducing glioma migration and invasion; and (ii) control of the tumorigenic host’s expression levels. This evidence concerns the gene TGFB1 and central nervous system cancer.