In two genetically engineered mice models of PDAC (KPC: “Ptf1-Cre/KrasLSL-G12D/+/p53LSL-R172H/+” and iKRAS: “Ptf1-Cre/ROSA26-LSL-rtTa-IRES-eGFP/TetO-KrasTetO-LSL-G12D/p53L/+”), Incio et al. [40] demonstrated that cancer-associated adipocytes (CAAs) through the production of pro-inflammatory cytokines, mainly IL1B, determine the activation of PSC, the recruitment/activation of tumor-associated neutrophils (TANs) with decreased CD8+ T cells, and increased Treg with a relative immunosuppressive microenvironment that promotes, in turn, tumor growth and metastasis. Here, CD8A is linked to neoplasm.