In a genetically engineered mice model (GEMM) of pancreatic cancer (KC: “LSL-KrasG12D and PDX-1-Cre”), the increase in visceral fat, including intrapancreatic and peripancreatic fat, causes a systemic and local inflammatory state, with a greater production of pro-inflammatory cytokines, which are able to recruit immune cells in the pancreas and determine an acceleration of the tumor growth and a more aggressive tumor phenotype [10]. Here, PDX1 is linked to neoplasm.