Overall, in PDAC, cancer-associated adipocytes interacting with the cells of innate immunity through inflammatory cytokines, including IL-1b and LCN2, determine an immunosuppressive environment, due to the increase in TANs and Treg, and a decrease in CD8+ lymphocytes and a fibrous environment that participates in tumor progression and intrinsic chemoresistance. This evidence concerns the gene LCN2 and neoplasm.