XRCC1 and hepatocellular carcinoma: Additionally, for c.1517G > C XRCC1 gene polymorphism, at the level of IR subgroups, the comparison between IR-HCC group, IR-cirrhotic, and the control group showed a significantly higher frequency of heterozygote genotype GC, combined (GC + CC) and C allele in IR-HCC group more than the control.