Synthesis of anti-inflammatory cytokines including chemokine (C-C motif) ligand 2 (CCL2), tumor growth factor β (TGFβ), interleukin 10 (IL-10) that recruit regulatory T cells and myeloid derived suppressor cells (MDSC), and tumor-associated macrophages (TAMs) that inhibit T cell responses and promote tumor progression are also very common in GBM [240]. Here, CCL2 is linked to neoplasm.