Specifically, expression of galectin-9 that binds to T-cell immunoglobulin and mucin domain 3 (TIM-3) [236]; Fas ligand (FasL) that induces apoptosis of lymphocytes [237], B7 which is immunosuppressive to CTLA-4 [238], and programmed death ligand 1 (PD-L1) which is immunosuppressive to programmed death 1 (PD-1) expressing T-cells are significantly high in glioma cells [239]. Here, CTLA4 is linked to central nervous system cancer.