KCNK3 and pulmonary arterial hypertension: 2003, Gardener et al. 2004, Olschewski et al. 2006, Manoury et al. 2009). The non‐inactivating K current in rat, rabbit and human PASMCs has functional characteristics of TASK‐1 channels (Olschewski et al. 2017), although this may not be the case in mouse PASMCs (Manoury et al. 2009, 2011). TASK‐1 channels are important regulators of PASMC resting membrane potential and excitability. In rat models of PAH, TASK‐1 current decreased progressively during development of the disease and this was associated with a membrane depolarization (Antigny et al. 2016).