BMPR2 and pulmonary arterial hypertension: On thecontrary, a recent study demonstrated that hypermethylation in the BMPR2 promoterdoes occur in patients with heritable pulmonary arterial hypertension, resulting indown-regulation of BMPR2 expression (47).Together, these findings show that DNA methylation mechanisms involved in PAH arecomplex and unmistakable, take place on multiple genes, and are not the onlymechanisms associated with all forms of PAH.