A study analyzing whether alterations in DNA methylation patterncould be associated to BMPR2 mutations in 28 patients with iPAH and 27 patientsdiagnosed with PAH associated with other diseases found no difference in themethylation CpG islands of BMPR2 promoter region between the PAH patients andhealthy control subjects (46). The gene discussed is BMPR2; the disease is idiopathic pulmonary arterial hypertension.