A study analyzing whether alterations in DNA methylation patterncould be associated to BMPR2 mutations in 28 patients with iPAH and 27 patientsdiagnosed with PAH associated with other diseases found no difference in themethylation CpG islands of BMPR2 promoter region between the PAH patients andhealthy control subjects (46). This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.