Studies conducted on the fawn-hooded rat, whichdevelops PAH spontaneously, have demonstrated that treatment with5-aza-2′-deoxycytidine (a DNMT inhibitor) or with MnTBAP (a mimetic of SOD2), at adose of 10 mg/kg for 2 weeks, was capable of increasing SOD2 expression whilereducing the proliferative state of PASMCs, resulting in alleviated pulmonaryarterial hypertension (10,42). This evidence concerns the gene SOD2 and pulmonary arterial hypertension.