XCR1 and infection: Notably, the peak of EdU-labeled CD103+/XCR1+ DC did not exhibit the lag observed with RPM, Ly6Chi DC, or CD11b+ DC (Fig 3), suggesting that this subset of cells in the lung parenchyma does not depend on differentiation from a cell with another phenotype, and that CD103+/XCR1+ DC proliferate locally in the lungs, even in the absence of infection, as previously reported [26].