This region displays robust CENP-A occupancy in colon cancer cell lines in which CENP-A is naturally overexpressed (SW480, HT29), and also in early, mid, and late grade colorectal tumors, but not in normal tissues, or in cells that do not have high levels of CENP-A, such as HeLa or DLD-1 cells [17]. The gene discussed is CENPA; the disease is malignant colon neoplasm.