EGFR and non-small cell lung carcinoma: iDES-enhanced CAPP-Seq has shown to be highly sensitive in the detection of EGFR mutations with an allele frequency as low as 0.004% with >99.99% specificity using cfDNA of NSCLC patients; furthermore, the required amount for the library preparation was only 32 ng [95], making it a very practical test for investigating ctDNA.