Secreted ANXA1 interacts with FPRs and is involved in inflammation, neuroendocrine system regulation, skeletal muscle differentiation and cancer progression (Boudhraa et al., 2016), while nuclear translocation of ANXA1 is implicated in neuronal apoptosis after stroke (Zhao et al., 2015; Li et al., 2016). This evidence concerns the gene ANXA1 and cancer.