Here, our results presented that the expressions of MET proto-oncogene, receptor tyrosine kinase (MET), glutamate metabotropic receptor 8 (GRM8), cholinergic receptor nicotinic alpha 5 subunit (CHRNA5), and dachshund family transcription factor 1 (DACH1) were reduced in the SCLC patients with lymph node metastasis compared with those patients without lymph node metastasis. The gene discussed is CHRNA5; the disease is small cell lung carcinoma.