Besides, glutathione-disulfide reductase (GSR), human leukocyte antigen complex P5 (HCP5), and achaete-scute family bHLH transcription factor 1 (ASCL1) were upregulated in the SCLC patients with lymph node metastasis. The gene discussed is GSR; the disease is metastatic malignant neoplasm in the lymph nodes.