TNFSF11 and osteoporosis: Common examples of this type include glucocorticoid- and immobilisation-induced osteoporosis (Feng and McDonald, 2011), as well as inflammation-induced bone loss as the result of overexpression of RANKL by immune cells during periodontitis or rheumatoid arthritis (Schett and David, 2010; Redlich and Smolen, 2012).