Clinically, it is characterized by peripheral blood eosinophilia, increased levels of serum IgE, an immediate skin reaction and/or specific IgE/IgG antibodies to Aspergillus fumigatus due to type I and III hypersensitivity reactions, and radiographic findings including pulmonary opacities, central bronchiectasis, and mucus plugs (3–5). This evidence concerns the gene IGHE and skin reaction.