TP53 and Parkinson disease: As shown by Western blotting, total p53 protein level was highly increased in MPTP PD mice, and miR-212-5p treatment suppressed p53 expression (two-way ANOVA, MPTP: F1,18 = 5.690, p = 0.0283; genotype: F1,18 = 8.025, p = 0.0110; interaction: F1,18 = 8.648, p = 0.0087) (Figures 7I,J).