Moreover, given the well-described role of CNTF-induced differentiation in healthy cells (Rathje et al., 2011; Johnson et al., 2014), we suspect that CNTF-induced cell cycle arrest in iSCs likely takes advantage of differentiation-induced cell cycle arrest, which has for a long time been a promising avenue to treat cancer (Nguyen et al., 2016). This evidence concerns the gene CNTF and cancer.