NOTCH3 and T-cell acute lymphoblastic leukemia: This may also be triggered by the pre-T-cell receptor (pre-TCR) (30) whose functional cooperation with constitutive Notch3 expression is involved in the pathogenesis of a Notch3-induced T-cell acute lymphoblastic leukemia (T-ALL) (31) characterized by a wide CD4+CD25+Treg expansion (32, 33).