LAMP1 and Huntington disease: Lamp1, a marker for late-endosomes, lysosomes and autolysosomes, is known to be involved in lysosome biogenesis and autophagy (Eskelinen, 2006), and differential expression as well as colocalization with polyglutamine-containing aggregates in HD were already reported (King et al., 2008; Zheng et al., 2010).