MAP1LC3A and Machado-Joseph disease: In the cerebellum and oculomotor nucleus of SCA3 patients, autophagic proteins such as autophagy-related gene (Atg) protein ATG-7, -12, -16L2 and microtubule-associated proteins 1A/1B light chain 3A and B (MAP1LC3A/B) were significantly increased (Sittler et al., 2018).