Groveman and his colleagues demonstrated that RT-QuIC assay can be completed within just 1–2 days by exploiting a mutant recombinant α-synuclein substrate under optimized reaction conditions, so this assay is suitable for the detection of prodromal PD due to its rapid detection capability and high diagnostic accuracy (Groveman et al., 2018). Here, SNCA is linked to Parkinson disease.