MAPT and Parkinson disease: PD patients can be distinguished from MSA by the combined CSF t-tau and p-tau levels with a sensitivity of 82% and a specificity of 81% (Herbert et al., 2014); and an inverse relationship between p-tau/t-tau ratio in CSF and the UPDRS or UPDRS motor score (UPDRS III) has been already confirmed (Zhang et al., 2013).