The other three genes including SNCA, LRRK2 and VPS35 are found to lead to typical autosomal dominant PD (Guo et al., 2015; Shen et al., 2016); and analysis for genetic mutations in Parkin, DJ-1, PINK1, SNCA, LRRK2 and GBA are much of importance, which account for 2%–3% of PD patients. The gene discussed is SNCA; the disease is Parkinson disease.