CASR and cardiovascular disorder: Activation of CaSR has been reported to be involved in the development of various cardiovascular diseases including cardiac hypertrophy and apoptosis (Schepelmann et al., 2016; Paquot et al., 2017; Zhang et al., 2018), but the molecular mechanism of the involvement of CaSR activation in heart failure has not yet been clarified and thus needs to be further explored.