Upon review of the previous studies, it was found that CaSR contributes to cardiac hypertrophy induced by angiotensin II, Iso, and transverse aortic constriction, and the mechanism may involve [Ca2+]i, the sarcoplasmic reticulum (ER), the mitochondrial death pathway and autophagy (Wang et al., 2008; Lu et al., 2013; Liu L. et al., 2016). The gene discussed is AGT; the disease is cardiac hypertrophy.