Activation of CaSR has been reported to be involved in the development of various cardiovascular diseases including cardiac hypertrophy and apoptosis (Schepelmann et al., 2016; Paquot et al., 2017; Zhang et al., 2018), but the molecular mechanism of the involvement of CaSR activation in heart failure has not yet been clarified and thus needs to be further explored. The gene discussed is CASR; the disease is heart failure.