GLP1R and metabolic disease: Indeed, type 2 diabetes (T2D) is a metabolic disease reported to involve an impaired intestinal release of GLP-1 and its co-secreted peptides oxyntomodulin and glicentin (15–17), together with an insulinotropic resistance to GIP in the pancreas (18) which lead to a deficient incretin system, purportedly causing the disease (19, 20).