Agonism of GPR119 in both healthy or diabetic and obese mice, is known to improve glucose tolerance (90), or even prevent atherosclerosis in mice (332), while at the same time inducing the secretion of glucagon under low glucose levels avoiding hypoglycaemia (91); therefore since 2008, multiple agonists have been synthesized (239, 254, 333), as well as unimolecular dual DPP-4 inhibitors and GPR119 agonists (334). This evidence concerns the gene GPR119 and atherosclerosis.