GCG and type 2 diabetes mellitus: The key protease responsible for the processing of the proglucagon peptide into GLP-1 is Psck1/3, which has shown to be upregulated in α-cells during hyperglycaemic, hyperlipidemic, or inflammatory conditions to promote glucose-induced glucagon suppression, a compensatory response to a metabolic insult as in type 2 diabetes (205).