Beside these, Te Riele performed whole-exome sequencing in six ARVD/C patients without desmosomal variants and found a missense variant (R1898H) in SCN5A. Later, they expanded the study population and found almost 2% of ARVD/C patients had rare SCN5A variants (Te et al., 2017). The gene discussed is SCN5A; the disease is Arrhythmogenic right ventricular dysplasia.