Moreover, in a mouse model of chronic IgE-mediated skin allergy, IL-4 from basophils recruited to inflamed skin converted inflammatory into anti-inflammatory M2-macrophages (44, 45), while depletion of basophils exaggerated disease in mouse models for autoimmune colitis (46) as well as for multiple sclerosis [experimental autoimmune encephalomyelitis (EAE)] (47). Here, IGHE is linked to multiple sclerosis.