PSMA6 and Granuloma: Expression of IPSE/alpha-1 correlated with the maturation stage of the eggs: immature, freshly embolized eggs surrounded by only few recruited inflammatory cells and intact liver parenchyma (early granuloma formation) did usually not yet stain for IPSE/alpha-1, while IPSE/alpha-1 was detected in larger further developed eggs/granulomas in the typical subshell location.