Arrdc3 regulates the endosomal residence time and intracellular signaling of the β2 adrenergic receptor in HEK293 and BT549 cancer cell lines (Patwari et al., 2011; Tian et al., 2016), however, to our knowledge, there is no evidence in the literature for a role in the brain, where its transcript levels were found to be very low (Patwari et al., 2011). The gene discussed is ARRDC3; the disease is cancer.