An inverse relationship between CRP levels and cortical thickness in prefrontal regions is consistent with the elevated CRP patients with schizophrenia displaying a significantly worse working memory performance relative to patients with schizophrenia who display normal CRP levels; however, it is typically aberrant activity in the dorsolateral prefrontal cortex, not other prefrontal regions that is associated with changes in working memory in people with schizophrenia (72). This evidence concerns the gene CRP and schizophrenia.