Carum carvi extracts were also found to inhibit the 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin-dependent gene expression of cytochrome P450 1A1 in the rat hepatoma cells (54), therefore it may affect the drugs metabolyzed by CYP1A1 such as chlorzoxazone, theophylline, bufuralol. This evidence concerns the gene CYP1A1 and hepatocellular carcinoma.