They reported three main findings: first, survivin haplo-insufficient mice would reject syngenic kidney grafts due to the sustained inflammation and deficient tissue repair after a period of ischemia; the second finding was that survivin gene delivery (using plasmid vectors) could improve tissue survival in both syngenic and allograft models; finally, in fully mismatch transplantation models survivin overexpression resulted in better graft survival and less chronic allograft nephropathy. Here, BIRC5 is linked to Crouzon syndrome-acanthosis nigricans syndrome.