Musiał et al. studying chronic kidney disease (CKD) in children have observed increased amounts of survivin in patients' urine samples which was not in concordance with its serum level, so they suggested that this molecule is expressed in renal tissue probably as a protective factor against progressive damage and recommended survivin as a diagnostic maker in CKD follow-up; however, it could be presumed that survivin has been released and shed from tubules into the urine flow because of tissue destruction as a consequence of CKD pathogenesis [18]. This evidence concerns the gene BIRC5 and chronic kidney disease.