ACE and obesity due to melanocortin 4 receptor deficiency: The INVEST (International Verapamil SR-Trandolapril) trial and a post hoc analysis of the ACCOMPLISH (Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension) trial in particular found that individuals with obesity on calcium channel blockers (CCBs) and diuretics in combination with ACE inhibitors were at lower risk for experiencing a cardiovascular event than their lean counterparts [12, 13].