Previously published data of our group already revealed a decrease of colitis-inducing CD4+CD62Lhigh T cells after coculturing with DX5+NKT cells [7], and consistent in both settings, DX5+ T cells decreased IFN-γ production of OVA-specific CD4+ T cells as well as of CD4+CD62Lhigh T cells as shown in our study [41, 42]. Here, CD4 is linked to colitis.