Concerning the comparison of the diagnostic performance between synovial fluid biomarkers for PJI diagnosis, although this study demonstrated a good accuracy of SF-PCT for PJI diagnosis with an AUC of 0.87, this diagnostic accuracy appeared to be slightly inferior to biomarkers from previous studies—such as CRP, IL-6, and alpha-defensin—with AUC between 0.90 and 0.99 [18, 20, 23, 24]. This evidence concerns the gene CALCA and juvenile polyposis syndrome.