On the contrary, rats in the finasteride-treated group demonstrated a significantly reduction of serum IL-8 and TNF-α level (10.48 ± 0.76 ng/ml and 1.13 ± 0.05 ng/ml, respectively, P<0.01) compared with the BPH group. This evidence concerns the gene CXCL8 and benign prostatic hyperplasia.