In this regard, Lin et al. reported the beneficial effects of serine proteinase inhibitors in the Der p-induced asthma model, resulting in decreased airway hyperresponsiveness and remodeling, eosinophil and neutrophil infiltration, the Der p-induced IL-4 levels in serum, and Th2 and Th17 cytokines profiles in BALF [13]. This evidence concerns the gene IL4 and asthma.