The mechanisms underlying the effects of exercise on breast carcinogenesis are not clear, but experimental evidence suggests that PA induces phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB also known as Akt)/mammalian target of rapamycin (mTOR) (PI3K-Akt-mTOR) signaling inhibition and slows TNBC tumor cell growth [12–14]. The gene discussed is PIK3CA; the disease is neoplasm.