Subsequently, we validated the 14 genes above in GSE17548 profile, which compared DEGs between tumor and cirrhosis tissues in HCC, and 13 genes (BUB1B, CCNA2, CCNB1, CCNE2, CDC20, CDC6, CDC7, CDK1, CDK4, CDKN2A, CHEK1, MAD2L1, and MCM3) were identified finally. The gene discussed is CDK4; the disease is hepatocellular carcinoma.