Additionally, overexpression of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in HCC tissues accounted for poorer OS in HCC patients (Log rank P = 0.000529, 0.000127, 0.0249, 0.0000352, and 0.0491, respectively, Figure 3 and Supplementary Table 2). Here, BUB1B is linked to hepatocellular carcinoma.