Upregulated BUB1B, CCNB1, CDC7, CDC20, and MCM3 in HCC tumor tissues also contributed to worse DFS in HCC patients (Log rank P = 0.000052, 0.0192, 0.0307, 0.00496, and 0.0284, respectively, Figure 4 and Supplementary Table 3). The gene discussed is CDC7; the disease is hepatocellular carcinoma.