Sequence alignment with the susceptible control Nipponbare detected a total of 194 and 245 NBS-LRR encoding genes with large-effect genetic variations in Huaye 3 and Huaye 4, including six blast resistance genes (Pit, LOC_Os01g05620; Pi9, LOC_Os06g17900; Pi36, LOC_Os08g05440; Pi56(t), LOC_Os09g16000; Pia, LOC_Os11g11790; Pi5, LOC_Os11g11810), two BPH resistance genes (Bph14, LOC_Os03g63150; Bph26, LOC_Os12g37280), two bacterial blight resistance genes (Xa-1, LOC_Os04g53120; OsRP1L1, LOC_Os05g30220), and one defense response gene (NLS1, LOC_Os11g14380) (Table S11). This evidence concerns the gene IRF6 and benign prostatic hyperplasia.