Because both SCD-1 and CD36 were regulated by PPARγ, the expression of PPARγ1, PPARγ2, and PGC1α was evaluated; interestingly, the expression of PPARγ2 and PGC1α was decreased only in HF-fed pioglitazone-treated CAR−/− mice (Figure 4(b)). Here, PPARGC1A is linked to hydrops fetalis.