The hyperexpression of WNT target genes corresponds with the hyperactivated WNT pathway in primary CRC and CRC cancer cell lines, most likely resulting from the biallelic inactivation mutation of APC, FBXW7, AXIN2, and FAM123B or the activating mutations in CTNNB1 [2, 6]. This evidence concerns the gene AMER1 and colorectal carcinoma.