PML and Hutchinson-Gilford progeria syndrome: Figure 6B indicates that MG132 induced an increase in Nox4 levels both in the cytoplasm but also into the PML nuclear foci. Since it has been demonstrated [35] that the effect of MG132 in Hutchinson-Gilford progeria syndrome (HGPS) fibroblasts unexpectedly resulted in a decrease of progerin staining intensity, instead of increasing progerin levels, we carried out immunofluorescence experiments for farnesylated prelamin A. As shown in Fig.6B, 8-h treatment with MG132 induced the formation of large farnesylated prelamin A and PML intranuclear foci, not a decrease.