Background: Data about correlation of interleukins (IL‐1α, IL‐1β, IFNγ, IL‐2, IL‐4, IL‐6, IL‐8, IL‐10), adipocytokines (leptin, adiponectin, monocyte chemoattractant protein‐1 [MCP‐1], resistin, plasminogen activator inhibitor‐1 [PAI‐1], tumour necrosis factor alpha [TNFα]), ferritin, C reactive protein (CRP) and vascular endothelial growth factor (VEGF)) with homeostasis model assessment (HOMA) in HIV/AIDS patients are still limited. The gene discussed is LEP; the disease is AIDS.