The effect of demographic and disease covariates, including age, sex, body weight (BW), body mass index, race, ethnicity, glomerular filtration rate, fasting versus fed administration status, infection status (HIV+ vs. HIV‐), antiretroviral treatment status (naïve vs. virally suppressed), HBV and HCV co‐infection status, baseline HIV‐1 RNA, baseline CD4 count, concomitant H2‐receptor antagonist (H2RA) administration and concomitant proton pump inhibitor (PPI) administration on the PK of BIC and TAF were evaluated. Here, CD4 is linked to coinfection.