Results: Of the 486 HIV+ patients included in the cohort, 84 were diagnosed with anal HSIL, 86.9% were MSM and 13.1% were women, with an average age of 36 years, 29.8% had history of AIDS, CD4 nadir of 346.5 cells/uL, 83.3% received ART of which 84.2% had viral load HIV <50 copies/μL with 652 CD4+ lymphocytes cells/uL. The gene discussed is CD4; the disease is AIDS.