At the three observed timepoints mean gamma‐GT increased from 49 U/L to 70 U/L (p = 0.001) and decreased to 53 U/L, respectively, CRP increased from 2.1 to 7.4 mg/dL and decreased after treatment to 1.6 mg/dL (p = 0.002) and the mean CD4 count dropped from 670/μL to 646/μL at time of syphilis diagnosis and increased significantly after treatment to 715/μL (mean, p = 0.022). This evidence concerns the gene CRP and syphilis.