Patients with VF were 69.6% males, mean age 45 (IQR 38 to 51) years, Caucasians 85.7%, with time of known HIV infection 15 (IQR 10 to 19) years, 45.5% sexual acquisition, nadir CD4 97 cells/mm3 and 69.1% AIDS stage, without finding differences between INSTI. This evidence concerns the gene CD4 and HIV infectious disease.