Compared to HBV‐negative patients, a significantly higher number of AIDS and non‐AIDS events were documented in the group of anti‐HBc‐positive subjects (41.1% vs. 19.1%, p = 0.002 and 56.5% vs. 28.7%, p = <0.0001, respectively) who, after ART initiation, reached viral undetectability in significantly longer time (six vs. four months, p = 0.0001). Here, KRT88P is linked to AIDS.