two aromatic sulfonamides (TR1 and GA15) were found to induce apoptosis in cancer cells due to stimulation of oxidative stress by increased ceramide and p38-MAPK, after intracellular acidosis due to CA IX inhibition, in human renal carcinoma cell lines and in HeLa cells, regulating CA IX expression driven by cell density11,.29 Here, CA9 is linked to renal carcinoma.