Moreover, we also demonstrated that the CAIX inhibitor SLC-0111 is able not only to prevent such CAIX increased expression but also to selectively induce the apoptotic program in A375-M6 melanoma cells, MCF7 breast cancer cells, and HCT116 colorectal cancer cells transiently and chronically exposed to extracellular acidosis, without showing any cytotoxic effect in the population maintained under standard pH condition (pH 7.4 ± 0.1).10 This evidence concerns the gene CCL21 and melanoma.