F5 and Down syndrome: Among the second 13 women, characteristics included previous cesarean (n=2), history of transfusion because of atony (n=1), pulmonary embolism (n=1), HELLP (hemolysis, elevated liver enzyme levels, and low platelet levels) syndrome (n=1), factor V Leiden mutation (n=1), anemia because severe iron deficiency (n=1), pulmonary embolism (n=1), Couvelaire uterus (n=1), and placenta increta (n=1).