The especially detriment result of the P2X7 activation is the enhanced release into the intercellular spaces the proinflammatory cytokines, mainly IL1-β, in which elevated levels have been detected in the AD brains, but also IL-18, IL-6, IL1-α, INF-γ, and TNF-α, which are responsible for the progression of Alzheimer’s disease [100]. This evidence concerns the gene P2RX7 and early-onset autosomal dominant Alzheimer disease.