Zhao et al. [16], designed and synthesized selective estrogen receptor modulators (SERMs) based on diphenylmethylene scaffold by incorporating some of the structural features of the aromatase inhibitor letrozole into lead compound (norendoxifen) by bis-Suzuki coupling to generate a series of selective anti-breast cancer agents to address the problem of E, Z isomerization related with norendoxifen. The gene discussed is ESR1; the disease is breast cancer.