A panel of AML cell lines (OCI-AML2, OCI-AML3, HL60, ML-1, Molm-13) were cultured with HS-5 cells for 24 h and changes in the expression of Bcl-2, Bcl-XL and Mcl-1 were determined with Western blotting. The gene discussed is BCL2L1; the disease is acute myeloid leukemia.