Our previous study found that AngII also modulated the mRNA expression of NF-κB family members however, Ang1–7 and AngII have clearly the opposite effect on the level of NFKBs expression: AngII significantly decreased the expression of NFKB1 mRNA in all prostate cancer cells while NFKB2 did so only in the PC3 cell line. The gene discussed is NFKB2; the disease is Familial prostate cancer.