On the other hand, the expression of the REL (REL proto-oncogene nuclear factor-κB subunit), RELA (RELA proto-oncogene nuclear factor-κB subunit) and RELB (RELB proto-oncogene nuclear factor-κB subunit) genes were down-regulated by Ang1–7 in all prostate cancer cells; however, the decrease was not statistically significant for the PC3 line. Here, REL is linked to Familial prostate cancer.