Our previous study found that AngII also modulated the mRNA expression of NF-κB family members however, Ang1–7 and AngII have clearly the opposite effect on the level of NFKBs expression: AngII significantly decreased the expression of NFKB1 mRNA in all prostate cancer cells while NFKB2 did so only in the PC3 cell line. Here, NFKB1 is linked to Familial prostate cancer.