During the 2-year follow-up period, the recurrence rate was 1.7% (1/58), 14.8% (12/81) and 28.1% (9/32) in patients who possessed no risk factors, one risk factor and both risk factors (tumor >5 cm and MICA expression <30%), respectively (P < 0.001) (Fig. 3). This evidence concerns the gene MICA and neoplasm.