The Cancer Genome Atlas (TCGA) Research Network discovered that a cryptic splice site within exon 5 of CLDN18 activates the ARHGAP26 or ARHGAP6 splice acceptor, leading to the expression of CLDN18-ARHGAP fusion transcripts in gastric cancer, especially in the genomically stable (GS) tumors3. The gene discussed is ARHGAP26; the disease is gastric cancer.